Prions: Proteins go it alone
نویسندگان
چکیده
منابع مشابه
Can Chimps Go It Alone?
Consider a smart chimpanzee named M from a tribe afflicted with a form of Alzheimer’s disease. Think of M as a logspace-bounded Turing machine. M can do simple things like integer arithmetic and matrix multiplication, but M turns sullen and calls for help when asked to perform seemingly equally simple tasks, such as simulating deterministic tree and dag automata. Is M acting difficult or is she...
متن کاملPrions and prion-like proteins.
Prions are self-replicating protein aggregates and are the primary causative factor in a number of neurological diseases in mammals. The prion protein (PrP) undergoes a conformational transformation leading to aggregation into an infectious cellular pathogen. Prion-like protein spreading and transmission of aggregates between cells have also been demonstrated for other proteins associated with ...
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P2X receptors (P2XR) function as ATP-gated nonselective ion channels permeable to Na+, K+, and Ca2+, and they are expressed in a wide range of excitable, epithelial/endothelial, and immune effector cell types. The channels are trimeric complexes composed of protein subunits encoded by seven different P2XR genes expressed in mammalian and other vertebrate genomes. Current genetic, biochemical, a...
متن کاملPrions: The New Biology of Proteins
Prions are believed to be the causative agents of a group of rapidly progressive neurodegenerative diseases called transmissible spongiform encephalopathies, or prion diseases. They are infectious isoforms of a hostencoded cellular protein known as the prion protein. Prion diseases affect humans and animals and are uniformly fatal. The most common prion disease in humans is Creutzfeldt-Jakob di...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2004
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn1398